San Francisco 49ers at Chicago Bears odds, choices and predictions To kick off the 2022 NFL season, the San 

Francisco 49ers (0-zero) are on the road to face the Chicago Bears (0-zero) in an early recreation Sunday. Kickoff is at 1 p.M. ET at Soldier

 Field, and the sport will air regionally on FOX. Below, we analyze Tipico Sportsbook‘s traces around the 49ers vs. Bears odds, and make our professional 

NFL picks and predictions. The 49ers are coming off a ten-win season, a trip to the playoffs and an appearance inside the NFC

 Championship Game. The difference is this year their beginning quarterback may be 2021 No. 3 universal pick Trey Lance. Lance takes over

 for Jimmy Garoppolo, who stays on the group as a backup. The Bears hired coach Matt Eberflus to groom 2nd-12 months QB Justin Fields 

to be a franchise quarterback and get the crew returned to the postseason after a 6-11 2021 season. 49ers at Bears odds

Provided with the aid of Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full listing. Lines final 

updated Saturday at 12:25 p.M. ET. Money line (ML): 49ers -320 (guess $320 to win $a hundred) bet $a hundred to win $260)

Against the unfold (ATS): 49ers -6.5 (-one hundred twenty Bears +6.5 (+one hundred) Over/Under (O/U): 40.5 (O: -110 one hundred ten)